Volume 6, Issue 2, June 2018, Page: 25-29
Specific IgE for Aero and Food Allergens in Adult Chronic Urticaria Patients Without Other Allergic Diseases
Osama Mohamed Abdel Latif, Allergy and Clinical Immunology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Received: May 18, 2018;       Accepted: May 31, 2018;       Published: Jun. 13, 2018
DOI: 10.11648/j.iji.20180602.11      View  863      Downloads  57
Abstract
Chronic Urticaria (CU) is a diseases characterized by occurrence of spontaneous wheels observed by the patient for more than 6 weeks duration. The prevalence of CU varies from 0.5-5% in adult population. This is a disease of complex etiologies with more areas to be explored by researches. The aim of the study was to detect the Prevalence of allergen sensitizations among adult chronic urticaria patients without other allergic diseases. This study is a cross-sectional case control study. 70 patients with CU without evident cause and 50 healthy control individuals were included in the study. Patients with any other allergic diseases (such as Asthma, allergic Rhinitis, Allergic Conjunctivitis, Drug Allergy, atopic Dermatitis, Anaphylaxis….), patients with other chronic or systemic Diseases (such as Cardiac, respiratory, renal, hepatic, hematological, thyroid or other skin Diseases, etc….) and smokers were excluded from the study. Each patient and control individual was subjected to full medical history, complete medical examination and routine lab test. Determination of allergen-specific IgE (for 20 separate food and 20 aeroallergens) in serum for the patients was done by using EUROLINE Atopy Screen. Each of the patients and control groups were comparable according to age and gender. There was a significant difference between the CU patients and the control group as regard the prevalence of any allergen sensitization (65.7% for CU patients and 18% in control group) p<0.05. There was also a significant difference between the sensitized individual in each group as regard the number of allergens per each individual; for sensitized CU patients the mean was 3 allergens and interquartile range was (2-4), for the sensitized control individuals the mean was 2 and interquartile range was (1-2) with p= 0.014. The mostly frequent allergens were found in the CU sensitized patients was the house dust mite allergens (34.8% of the sensitized CU patients were sensitized to one or more of the two types of mites; dermatophagoides pteronyssinus and or dermatophagoides farinae). The study concluded that; a great prevalence of CU patients proved to be sensitized to common allergens which open the door to start a trials to examine the value of environmental control, food avoidance and specific allergen immunotherapy in this group of patients.
Keywords
Chronic Urticaria, Allergen-Specific IgE, Aero-Allergens, Food Allergy
To cite this article
Osama Mohamed Abdel Latif, Specific IgE for Aero and Food Allergens in Adult Chronic Urticaria Patients Without Other Allergic Diseases, International Journal of Immunology. Vol. 6, No. 2, 2018, pp. 25-29. doi: 10.11648/j.iji.20180602.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Bernstein, J. A., Lang, D. M., Khan, D. A., Craig, T., Dreyfus, D., Hsieh, F., Sheikh, J., Weldon, D., Zuraw, B., Bernstein, D. I. and Blessing-Moore, J., 2014. The diagnosis and management of acute and chronic urticaria: 2014 update. Journal of Allergy and Clinical Immunology, 133(5), pp. 1270-1277.
[2]
Zuberbier, T., Balke, M., Worm, M., Edenharter, G. and Maurer, M., 2010. Epidemiology of urticaria: a representative cross-sectional population survey. Clinical and experimental dermatology, 35(8), pp. 869-873.
[3]
Balp MM, Khalil S, Tian H, Gabriel S, Vietri J, Zuberbier T. Burden of chronic urticaria relative to psoriasis in five European countries. Journal of the European Academy of Dermatology and Venereology. 2018 Feb; 32(2):282-90.
[4]
Darlenski, R., Kazandjieva, J., Zuberbier, T. and Tsankov, N., 2014. Chronic urticaria as a systemic disease. Clinics in dermatology, 32(3), pp. 420-423.
[5]
Grattan C, Maurer M. Urticaria and angioedema. Zuberbier T, editor. Springer; 2010 Apr 30.
[6]
Kessel A, Helou W, Bamberger E, Sabo E, Nusem D, Panassof J, Toubi E. Elevated serum total IgE–a potential marker for severe chronic urticaria. International archives of allergy and immunology. 2010; 153(3):288-93.
[7]
Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, Agarwal S, Doyle R, Canvin J, Kaplan A, Casale T. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. New England Journal of Medicine. 2013 Mar 7; 368(10):924-35.
[8]
Kaplan A, Ledford D, Ashby M, Canvin J, Zazzali JL, Conner E, Veith J, Kamath N, Staubach P, Jakob T, Stirling RG. Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy. Journal of Allergy and Clinical Immunology. 2013 Jul 1; 132(1):101-9.
[9]
Wang L, Ke X, Kavati A, Wertz D, Huang Q, Willey VJ, Stephenson JJ, Ortiz B, Paknis B, Bernstein JA, Beck LA. Real-world treatment patterns and outcomes of omalizumab use in patients with chronic idiopathic urticaria. Current medical research and opinion. 2018 Jan 2; 34(1):35-9.
[10]
Böhme M, Lannerö E, Wickman M, Nordvall SL, Wahlgren CF. Atopic dermatitis and concomitant disease patterns in children up to two years of age. Acta dermato-venereologica. 2002 Mar 1; 82(2).
[11]
Vietri J, Turner SJ, Tian H, Isherwood G, Balp MM, Gabriel S. Effect of chronic urticaria on US patients: analysis of the National Health and Wellness Survey. Annals of Allergy, Asthma & Immunology. 2015 Oct 1; 115(4):306-11.
[12]
Spector SL, Tan RA. Effect of omalizumab on patients with chronic urticaria. Annals of Allergy, Asthma & Immunology. 2007 Aug 1; 99(2):190-3.
[13]
Büyüköztürk S, Gelincik A, Demirtürk M, Kocaturk E, Colakoğlu B, Dal M. Omalizumab markedly improves urticaria activity scores and quality of life scores in chronic spontaneous urticaria patients: a real life survey. The Journal of dermatology. 2012 May 1; 39(5):439-42.
[14]
Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, Durham S, Fokkens W, Gjomarkaj M, Haahtela T, Bom AT. The skin prick test–European standards. Clinical and translational allergy. 2013 Dec; 3(1):3.
[15]
Caliskaner Z, Ozturk S, Turan M, Karaayvaz M. Skin test positivity to aeroallergens in the patients with chronic urticaria without allergic respiratory disease. Journal of Investigational Allergology and Clinical Immunology. 2004 Jan 1; 14(1):50-5.
[16]
Mahesh PA, Kushalappa PA, Holla AD, Vedanthan PK. House dust mite sensitivity is a factor in chronic urticaria. Indian Journal of Dermatology, Venereology, and Leprology. 2005 Mar 1; 71(2):99.
[17]
Kulthanan K, Jiamton S, RUTNIN NO, Insawang M, Pinkaew S. Prevalence and relevance of the positivity of skin prick testing in patients with chronic urticaria. The Journal of dermatology. 2008 Jun 1; 35(6):330-5.
[18]
Liutu M, Kalimo K, Uksila J, Kalimo H. Etiologic aspects of chronic urticaria. International journal of dermatology. 1998 Jul 1; 37(7):515-9.
[19]
Zhou Y, Sheng M, Chen M. Detection and allergen analysis of serum IgE in pediatric patients with chronic urticaria.
[20]
Tupker RA, Monchy JG, Coenraads PJ. House‐dust mite hypersensitivity, eczema, and other nonpulmonary manifestations of allergy. Allergy. 1998 Dec 1; 53(s48):92-6.
[21]
Burks W. Skin manifestations of food allergy. Pediatrics. 2003 Jun 1; 111(Supplement 3):1617-24.
[22]
Zhou Y, Sheng M, Chen M. Detection and allergen analysis of serum IgE in pediatric patients with chronic urticaria. Pakistan Journal of Medical Sciences. 2018 Mar; 34(2):385.
[23]
Asarnoj A, Hamsten C, Wadén K, Lupinek C, Andersson N, Kull I, Curin M, Anto J, Bousquet J, Valenta R, Wickman M. Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: a BAMSE/MeDALL study. Journal of Allergy and Clinical Immunology. 2016 Mar 1; 137(3):813-21.
Browse journals by subject